Immunology, Pathology and Pathophysiology
Robert M. Herndon, M.D., Editor
Medical Publishing, 2003, 258 pages
"Knowledge has been described as being like an expanding
sphere with the volume of knowledge contacting a surface on the unknown."
This new comprehensive review of the many fields of basic and clinical
research that impact our understanding of multiple sclerosis has its basis in this
premise. In doing research on MS it is not enough to know clinical neurology
or neurochemistry or neuroanatomy or pathology; it is important to understand
the many other areas that relate to them. This volume provides an overview of
MS-related research and will benefit many investigators in the field and help to
advance our efforts to cure this, thus far intractable, disease.
It is now more than 160 years since the first
clinical-pathological descriptions of cases of multiple sclerosis and more than
130 years since the classic clinical description and development of diagnostic
criteria by Charcot, yet MS remains an enigma. After decades of intense effort to
find the cause, no cause has been clearly identified and the disease remains
poorly understood. Despite the introduction of immunomodulatory therapies and
immunosuppressive regimens, MS remains a devastating disease. While a great deal of progress has
been made, much remains to be done. Our understanding of the disease remains
limited, treatments remain inadequate, and comprehensive management all too rare.
This volume is an overview of the basic sciences
as they relate to MS that will provide clinicians and investigators a better
understanding of the basic aspects of the disease. While it is possible to find
excellent reviews of almost any aspect of MS, few attempts have been made to bring
these very different aspects together in a single source. This volume is a
companion to Multiple Sclerosis: Diagnosis, Medical Management, and Rehabilitation,
edited by Drs. Jack S. Burks and Kenneth P. Johnson. Together, they represent an
attempt to comprehensively cover the field of MS from basic research to
comprehensive management and to provide a broad overview for those interested in
understanding the disease better or in pursuing MS research.
Robert M. Herndon is Director of the
Department of Neurology at the Veterans AffairsMedicalCenter in Jackson, Mississippi; Professor of Neurology at the University of MississippiMedicalCenter; and Editor-in-Chief of the
International Journal of MS Care.