Contact Us | Print Page | Sign In | Register
News & Press: Industry News for MS (INforMS)

CMSC INforMS: #CMSC16 – MS Patients of African Descent May Fare Better on Alemtuzumab (Lemtrada)

Monday, June 6, 2016  
Posted by: Elizabeth Porco
Share |

A study, recently presented at the Consortium of Multiple Sclerosis Centers (CMSC) 2016 Annual Meeting in National Harbor, Md., showed MS patients of African decent might better benefit from treatment with alemtuzumab (Lemtrada) compared to subcutaneous interferon beta-1a (Rebif) – with lower rates of relapses evident over five years of treatment.

The CMSC 2016 meeting,  June 1-4, pooled dozens of MS researchers and clinicians worldwide for high level symposiums and other opportunities to discuss and share findings and care practices.

The study, “Patients of African Descent with Active Relapsing-Remitting Multiple Sclerosis Demonstrate Clinical and Radiologic Benefits with Alemtuzumab over 5 Years”, presented during the Disease Management, Imaging, and Therapeutics session, evaluated patients enrolled in the CARE-MS I and CARE-MS II studies.

Relapsing-remitting MS (RRMS) patients not previously treated and patients who did not respond adequately to treatment, were enrolled in the study. Patients received one course of alemtuzumab per year, or interferon beta-1a during the first two years. After that, alemtuzumab was administered when patients experienced a relapse or had increased lesion activity on magnetic resonance imaging (MRI) brain scans.

Supported by Genzyme and Bayer HealthCare Pharmaceuticals, the study was performed by investigators from the Multiple Sclerosis Treatment Center of Dallas in collaboration with other national MS centers. The core study included 46 patients of African descent. Among them, 35 received alemtuzumab and 11 received interferon beta-1a treatment.

Average annual relapse rates for the first two years were 0.19 for patients on alemtuzumab and 0.62 with interferon, further improving to 0.16 in the alemtuzumab group when calculating the average in a follow-up period of five years.

During the first two years, 33% of MS patients on alemtuzumab therapy showed no evidence of disease activity, compared to only 13% of patients on the interferon group. Among the alemtuzumab patients, 25% continued to have no evidence of disease activity during following years.

Alemtuzumab did not give rise to any serious adverse events linked to the treatment. The rate of serious infection was similar among the patients of African descent and the rest of the study group.

The authors concluded that patients of African descent are likely more responsive to MS treatment with alemtuzumab, compared to interferon beta-1a.

By Magdalena Kegel

Multiple Sclerosis News Today

CMSC Disclaimer 
The industry news information and articles are for informational purposes only, and are not intended to represent any trends, partnerships, commitments, or research of the Consortium of MS Centers or any of it's members in any way whatsoever, nor should any party be libel in any way to the reader or to any other person, firm or corporation reading this industry news section. Although the CMSC site includes links providing direct access to other Internet sites, CMSC takes no responsibility for the content or information contained on those other sites, and does not exert any editorial or other control over those other sites. CMSC is providing information and services on the Internet as a benefit and service in furtherance of CMSC's nonprofit and tax-exempt status. CMSC makes no representations about the suitability of this information and these services for any purpose.

The Consortium of Multiple Sclerosis Centers

3 University Plaza Drive, Suite 116 Hackensack, NJ 07601

Tel: 201.487.1050 | Fax: 862.772.7275