Contact Us | Print Page | Sign In | Register
News & Press: CMSC Industry News for MS (INforMS)

CMSC INforMS: Brain Activity Patterns Linked with Improved Learning and Memory in multiple sclerosis

Tuesday, January 21, 2020  
Posted by: Elizabeth Porco
Share |

A recent article by Kessler Foundation researchers demonstrated g people with multiple sclerosis (MS). The article, "Brain activation patterns associated with paragraph learning in persons with multiple sclerosis: The MEMREHAB trial," (doi: 10.1016/j.ijpsycho.2019.09.008 ) was epublished on October 20, 2019 by the International Journal of Psychophysiology. The authors are Olga Boukrina, Ph.D., Ekaterina Dobryakova, Ph.D., Veronica Schneider, BA, John DeLuca, Ph.D., and Nancy Chiaravalloti, Ph.D., of Kessler Foundation.

This study furthers understanding of the findings of prior MEMREHAB studies using the modified Story Memory Technique for memory rehabilitation in the population with multiple sclerosis (MS). Prior studies at Kessler Foundation showed improvement in learning and memory in response to treatment with mSMT in individuals with MS, and associated changes in brain activity on functional magnetic resonance imaging (fMRI) related to working memory and word encoding. Findings suggested that the treatment resulted in effects on cerebral activation and functional connectivity. In this study, brain activation was examined in a subset of 16 participants with MS from the MEMREHAB trial. The participants were randomized to treatment (n=6) or placebo control (n=10) groups, and tested for their ability to remember a paragraph, before and after treatment with mSMT. It was hypothesized that mSMT treatment may produce different brain activation patterns during paragraph encoding in the treatment group compared to the control group.

Participants in the treatment c=group exhibited decreased brain activity in the language network (LAN), default mode network (DMN), and executive control network (ECN). This pattern of reduced activation was associated with marginally significant improvement on the Rivermead Behavioral Memory Test with a large effect size noted between baseline and follow-up performance for the treatment group.

"The decreased brain activation seen in this study may be a sign of more efficient processing after treatment," said Dr. Boukrina, research scientist in the Center for Stroke Rehabilitation Research at Kessler Foundation. "At baseline, individuals with MS often show hyperactivation of cortical areas during cognitive tasks," she explained, "which may be a necessary compensation in order to complete the task like their counterparts without MS. After treatment, the task becomes less demanding for them, and this lower demand may account for the reduction in activation."

This study has important implications for cognitive research in MS. Identifying the regions of the brain associated with improvements in learning and memory may foster investigation into methods that may augment the beneficial activation patterns, such as pharmacological agents or transcranial magnetic stimulation. Combining therapies may be a means of achieving optimal behavioral response in individuals with MS affected by cognitive deficits.

By Kessler Foundation

Medical Xpress

CMSC Disclaimer 
The industry news information and articles are for informational purposes only, and are not intended to represent any trends, partnerships, commitments, or research of the Consortium of MS Centers or any of it's members in any way whatsoever, nor should any party be libel in any way to the reader or to any other person, firm or corporation reading this industry news section. Although the CMSC site includes links providing direct access to other Internet sites, CMSC takes no responsibility for the content or information contained on those other sites, and does not exert any editorial or other control over those other sites. CMSC is providing information and services on the Internet as a benefit and service in furtherance of CMSC's nonprofit and tax-exempt status. CMSC makes no representations about the suitability of this information and these services for any purpose.

The Consortium of Multiple Sclerosis Centers

3 University Plaza Drive, Suite 116 Hackensack, NJ 07601

Tel: 201.487.1050 | Fax: 862.772.7275

info@mscare.org